Patient Record · MRN SMC-453037

SYN-079

[SYN] Whiskey Kepler · 64y · Female · Indian · BMI 27.4 · ECOG 1

SVMC - Sunway Velocity · Cardiothoracic Surgery · Dr. Ng Wei Sheng

IA1 (T1a, N0)Disease-free

KRAS G12CTP53

Clinical storyline

[SYN] Whiskey Kepler, a 64-year-old Indian female (former, 10 pack-years, ECOG 1), presented in 2023-09 with right-sided chest discomfort. Workup confirmed Adenocarcinoma (Stage I, KRAS G12C). The MDT recommended curative-intent surgery. Current status: Disease-free.

HPE Results

Adenocarcinoma: Solid, poorly differentiated, KEAP1/STK11 co-mut (immune-cold)

Clinical Stage

IA1 (T1a, N0)

Pathological Stage

IA1 (T1a, N0, Mx)

Adenocarcinoma Subtype

Solid, poorly differentiated

CEA (ng/mL)

6.5

Tumor (CT/PET)

2.4 cm

PET SUV

10.85

NGS Results

1. 1. KRAS G12C
2. KEAP1 loss-of-function
3. STK11 loss-of-function
2. TP53 R175H